Welcome to TCMNPAS!

LongHua Hospital Shanghai University of Traditional Chinese Medicine

TCMNPAS: A comprehensive analysis platform for exploring traditional Chinese medicine The TCM Network formulaology and Pharmacology Analysis System (TCMNPAS), registered with the National Copyright Administration of China under the registration number 2019SR1127090. TCMNPAS incorporates multiple resources and offers a range of functions designed for automated analysis implementation, including prescription mining, molecular docking, network pharmacology analysis, and visualization. The online version of TCMNPASv1.0 system offers 8 functional modules for users.

Citation:

1.Liu, Y., Li, X., Chen, C., Ding, N., Zheng, P., Chen, X., Ma, S., & Yang, M. (2024). TCMNPAS: a comprehensive analysis platform integrating network formulaology and network pharmacology for exploring traditional Chinese medicine. Chinese medicine, 19(1), 50. https://doi.org/10.1186/s13020-024-00924-y. 2.LongHua Hospital Shanghai University of Traditional Chinese Medicine,YangMing. TCM Network Pharmacology Analysis System v1.0[CP/CD],Copyright Registration No.,2019SR1127090. 3.Yang Ming. (2024). tcmnpas: A comprehensive analysis platform for exploring traditional Chinese medicine. GitHub. https://github.com/yangpluszhu/tcmnpas. GPL-3.0 License.

Note： Due to TCMNPAS being a computationally intensive web application, multiple entry channels have been opened to alleviate server pressure. Please do not restrict yourself to using a single channel. If a particular entry is unable to log in, it may be due to that channel being under high load. Please try logging in through different entry channels. This system is free to use and is intended solely for academic research purposes. This system provides video tutorials: [Click here to access] The Network Pharmacology Special Committee of the World Federation of Chinese Medicine Societies (WFCMS) released the [Network Pharmacology Evaluation Method Guidance] on March 8, 2021. Entry Channels Channel1:【Click here to access Chinese Version】 Channel2:【Click here to access Chinese Version】 Channel3:【Click here to access Chinese Version】 Channel4:【Click here to access Chinese Version】 Channel5:【Click here to access English Version】 Channel6:【Click here to access English Version】 Channel7:【Click here to access English Version】 Channel8:【Click here to access English Version】 [2024-06-23]Note: Recently, the TCMNPAS website has encountered a substantial increase in traffic. In order to ensure the stable operation of the server, the system will automatically disconnect threads that have been active for more than 48 hours.

Update log:

2024-07-25: Updated KEGG data to Release 111.0, July 1, 2024.
2024-01-04: Updated KEGG data to Release 109.0, January 1, 2024.
2023-10-30: Addition of Lipinski and Veber rules for drug-likeness screening.
2023-8-10: English version of TCMNPAS is online.
2023-7-23: Updated reactome.db to current Release v1.84.0.Updated GO.db to current Release v3.17.0.Updated Gene Ontology knowledgebase to 2023-01-01.
2023-7-11: Updated HIPPIE data to current Release v2.3.
2023-7-9: Updated KEGG data to Release 107.0, July 1, 2023.
2023-2-12: Updated GeneCards-malacards disease gene search module.
2022-10-06: Updated KEGG data to Release 104.0, October 1, 2022; added importance scoring based on binomial distribution for key target genes and compounds.
2021-11-26: Fixed mining errors caused by certain prescription input formats in the prescription mining module.
2021-9-23: Updated clusterProfiler to v4.0.2 and fixed some errors that occurred after the update.
2021-8-11: Updated KEGG data to Release 99.1, August 1, 2021.
2020-11-23: Batch docking module supports multiple docking parameters for the same protein. Corrected errors in CUSTOM target database where gene IDs for certain components were 0.
2020-10-13: Updated KEGG data to Release 96.0, October 1, 2020.